The first part of the course includes an introduction to the discipline of Pharmacogenomics, accompanied by an historical perspective. This part also refers to the analytical methods used in pharmacogenomic testing.
The second part of the course includes examples from the clinical applications of pharmacogenomics. In particular, examples of use cases in oncology, cardiology, psychiatry, infectious diseases, transplantation, etc are discussed, focusing in particular on the corresponding drug-gene-pharmacogenomic biomarker combinations, focusing in particular on the required dose adjustements.
The third part of the course discusses the impact of population differences in the prevalence of pharmacogenomic biomarkers and their role in population pharmacogenomics. It also alludes to the complex phenotypes and rare drug outcomes resulting from rare pharmacogenomic variants. Lastly, this part summarizes the various regulatory aspects of pharmacogenomics and their role in drug development
The fourth part of this course provides an outline of databases and other useful resources for Pharmacogenomics, such as the PharmGKB knowledgebase, etc. It also discusses the various new trends in the pharmacogenomics field, such as pharmacometabolomics-aided pharmacogenomics and the application of whole genome sequencing in pharmacogenomics.
The fifth and final part of the course is dedicated to the various ethical aspects of pharmacogenomics and the implications of the accompanying pharmacogenomics-related legislation. Lastly, this part discusses the role and impact of Pharmacogenomics on public health.
Personalized Medicine
1. Introduction and history of Personalised Medicine.
2. Pharmacogenomics in Cardiology (examples and case discussion)
3. Pharmacogenomics in Oncology (examples and case discussion)
4. Pharmacogenomics in Psychiatry (examples and case discussion)
5. Electronic tools for translational pharmacogenomics
6. Regulatory aspects in Pharmacogenomics
7. Pharmacogenomics and whole genome sequencing
8. Population Pharmacogenomics
9. Ethical implications in genome-guided therapeutics
10. Public Health Pharmacogenomics
11. Conclusions and future perspectives
12. Recap and evaluation